Created and executive-produced by Emmy Award-winning writer Linwood Boomer, this inventive half-hour series is seen through the eyes of MALCOLM (Frankie Muniz), a regular high school kid trying to navigate his way through life despite the various obstacles thrown in his way – a complete misunderstanding of girls, the constant burden of masterminding plans to get himself and his brothers into or out of trouble, and a miserable job at the Lucky Aide… not to mention a severe case of teen angst.

Although Malcolm has a genius IQ, he can’t seem to make sense of the opposite sex, much less his embarrassing family. LOIS (Jane Kaczmarek) is the outspoken, opinionated mom, who still manages to rule the roost even though her boys are growing wise to her crafty ways. HAL (Bryan Cranston), a dad who is just a bumbling, big kid at heart, often finds himself creating more chaos than his five boys combined. REESE (Justin Berfield) has mastered the art of a perfect blank stare, and makes up for his lack of intelligence with deviance.

FRANCIS (Christopher Masterson), Malcolm’s oldest and favorite brother, is willing to move from Alabama to Alaska to New Mexico – as long as its keeps him from moving back home. DEWEY (Erik Per Sullivan), no longer the youngest, has learned his tricks from the best and often pulls the wool right over his brothers’ eyes. And then there’s Jamie, the newest member … and family scapegoat.

 

Malcolm: main character, genius boy, played by Frankie Muniz

Francis: Malcolm's oldest brother, played by Christopher Masterson

Reese: Malcolm's older brother, played by Justin Berfield

Dewey: Malcolm's younger brother, played by Erik Per Sullivan

Lois: Malcolm's overbearing mother, played by Jane Kaczmarek

Hal: Malcolm's father, played by Bryan Cranston

 

Stevie: Malcolm's friend in a wheelchair, played by Craig Lamar Traylor

Caroline: Malcolm's teacher, played by Catherine Lloyd Burns

Cynthia: Malcolm's nerdy little female friend, played by Tania Raymonde

Dabney: Malcom's nerdy male friend, played by Kyle Sullivan

Edwin Spangler: Francis' boot camp leader, played by Daniel Von Bargen

Abe: Next door neighbour, & hal's friend, Steve's father, Gary Anthony Williams

Piama: Francis' wife, played by emy coligado

Craig: Works with Louis at the store, played by david anthony higgin

Otto: Francis' boss, when he works at a farm, Kenneth Mars

Gretchin: Otto's wife, played by Meagen Fay

Ida: Malcolm's grandmother, played by Cloris Leachman